Application of Forensic DNA Identification to Human Cell Line Authentication

Rapid DNA Re-Identification for Cell Line Authentication and Forensics

Authentication of forensic DNA samples.

Over the past twenty years, DNA analysis has revolutionized forensic science, and has become a dominant tool in law enforcement. Today, DNA evidence is key to the conviction or exoneration of suspects of various types of crime, from theft to rape and murder. However, the disturbing possibility that DNA evidence can be faked has been overlooked. It turns out that standard molecular biology techn...

Identification of Novel Hypoxia Response Genes in Human Glioma Cell Line A172

  Objective(s): Hypoxia is a serious challenge for treatment of solid tumors. This condition has been manifested to exert significant therapeutic effects on glioblastoma multiform or (WHO) astrocytoma grade IV. Hypoxia contributes numerous changes in cellular mechanisms such as angiogenesis, metastasis and apoptosis evasion. Furthermore, in molecular level, hypoxia can cause induction of DNA br...

Forensic Application of Speaker Identification

This paper describes a forensic application scenario in the speaker recognition domain and explains the techniques required to develop a complete forensic analysis system based on speaker identification. It is presented a standard manner of how Gaussian Mixture Models (GMMs) could be used in order to compute and express identification results in a judicial system. A review of possible technique...

Mouse cell line authentication

The scientific community has responded to the misidentification of human cell lines with validated methods to authenticate these cells; however, few assays are available for nonhuman cell line identification. We have developed a multiplex polymerase chain reaction assay that targets nine tetranucleotide short tandem repeat (STR) markers in the mouse genome. Unique profiles were obtained from se...